An Exciting Time for Research into CTEPH Discussed in Review Article

Patients with pulmonary hypertension may be surprised to know that the disease can sometimes be accompanied by the complication known as thromboembolic pulmonary hypertension (CTEPH). Pulmonary embolisms are the root cause of CTEPH because a pulmonary embolism (a blood clot in the lungs) that fails to be degraded via thromboembolysis can become lodged in blood vessels leading to the lungs and occlude blood flow. Individuals without any history of pulmonary embolisms are susceptible to CTEPH, making it important to understand the pathophysiology, risks factors, and signs of CTEPH.

 

As suggested by a recent review entitled, “Chronic Thromboembolic Pulmonary Hypertension: the End Result of Pulmonary Embolism,” which was published in Current Cardiology Reports, it is an exciting time for researchers in the field of CTEPH and patients who suffer from the disease. A lot of progress has been made in understanding CTEPH, leading to better diagnosis techniques and therapeutic options.

“Although it is generally believed that CTEPH originates with acute venous thromboembolism, interestingly, up to 40% of CTEPH patients will have no antecedent history suggestive of acute pulmonary embolism,” wrote Dr. Alison S. Witkin and Dr. Richard N. Channick, of the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital in Boston.

Often times, CTEPH symptoms are confused with those of other cardiac and pulmonary diseases, which can lead to delays between first notice of symptoms and CTEPH diagnosis. Shortness of breath, progressive exercise intolerance, and chest pain are all indicators of some form of pulmonary hypertension. However, a large difference between pulmonary arterial hypertension and CTEPH is the type of blood vessels that are affected. Pulmonary arterial hypertension affects blood vessels smaller than 300 micrometers in size, while CTEPH affects larger blood vessels that are closer to the heart.

Since patients and their clinicians may not suspect CTEPH is the root cause of symptoms due to the disconnect between patient history and the ease of coming to an improper diagnose, it is important to have a standard technique to diagnose CTEPH. Commonly, ventilation perfusion scans are used to suggest CTEPH, but the gold standard to properly diagnose CTEPH is via right heart catheterization and pulmonary artery angiogram. These may be performed when patients have the indicative symptoms for CTEPH and have some of the common risk factors: idiopathic pulmonary embolism, large perfusion defects, and a right ventricular systolic pressure greater than 50 mmHg.

Once properly diagnosed, CTEPH, unlike other forms of pulmonary hypertension, can be cured by the surgical procedure known as pulmonary thromboendarterectomy (PTE). Recently, a medication developed by Bayer, Adempas (riociguat), was approved by the Food and Drug Administration for patients with CTEPH. Adempas is also indicated for pulmonary arterial hypertension, as the drug acts to increase vessel diameter to allow blood to flow more easily, reducing the pressure the heart must work against to pump blood to the lungs.

Because there are viable treatment options for those with CTEPH, the most significant unmet medical need for addressing the disease is improving early detection, since patient outcomes are hinged on how early an accurate CTEPH diagnosis is made. With researchers making substantial progress in improving early detection of CTEPH, the medical community is becoming increasingly capable of treating and curing people with the disease.

Comment

  • Bessie Bessie Thursday, 02 July 2015

    Is dedicated to offering information on pure and
    alternative health, however will not be written by health care
    professionals.

  • Etsuko Etsuko Thursday, 02 July 2015

    This is my first time visit at here and i am genuinely impressed to read everthing at alone place.

  • Fredric Fredric Thursday, 02 July 2015

    An internet web page session time is specified on the server aspect, subsequently this is nnot
    a setting you may regulate or change on your laptop or in your web browser.

  • Gena Gena Thursday, 02 July 2015

    What i do not understood is in truth how you are no
    longer really a lot more well-preferred than you might be right now.
    You're very intelligent. You recognize thus considerably with
    regards to this subject, produced me in my view
    believe it from numerous varied angles. Its like women and
    men don't seem to be interested until it's one thing to accomplish with Girl gaga!

    Your individual stuffs excellent. At all times take care of
    it up!

  • Britney Britney Thursday, 02 July 2015

    Its such as you learn my thoughts! You seem to grasp a lot about this, like you
    wrote the ebook in it or something. I think that you could do
    with a few percent to power the message house a bit, however other
    than that, that is wonderful blog. An excellent read.
    I will definitely be back.

  • Izetta Izetta Thursday, 02 July 2015

    Thank you, I have just been searching for info approximately this topic for a long time and yours is the best I have came upon so far.
    But, what about the bottom line? Are you positive in regards to the source?

  • Julie Julie Thursday, 02 July 2015

    Hey there! Do you know if they make any plugins to help with SEO?
    I'm trying to get my blog to rank for some targeted keywords but
    I'm not seeing very good success. If you know of any please
    share. Many thanks!

  • King King Thursday, 02 July 2015

    Hello Dear, are you truly visiting this site regularly,
    if so then you will absolutely obtain fastidious experience.

  • Nina Nina Thursday, 02 July 2015

    They also ship rapidly to just about every portion of the country when you
    purchase from their official New Zealand shop.

  • Lilian Lilian Thursday, 02 July 2015

    My developer is trying to convince me to move to .net from PHP.
    I have always disliked the idea because of the costs.
    But he's tryiong none the less. I've been using Movable-type
    on numerous websites for about a year and am worried about switching to
    another platform. I have heard good things about
    blogengine.net. Is there a way I can import all my wordpress content into it?
    Any help would be really appreciated!

Leave your comment

Make sure you enter the (*) required information where indicated. HTML code is not allowed.

About Us

The Saudi Association for Pulmonary Hypertension (SAPH) is a medical and research national group of many medical specialists, who shared a common interest in the field of pulmonary vascular disease. The main goal for SAPH is to increase the awareness and the knowledge of pulmonary vascular diseases in the society and between the medical professionals.

The Saudi Association for Pulmonary Hypertension (SAPH) is a Subsidiary of The

Saudi Association for PH

STS office (Exit 11 & the Airport Road)

Riyadh, Saudi Arabia

P. O. Box 106911
Riyadh 11676
Saudi Arabia

Tel:+966-11-2488966
Fax: +966-11-2487431
Mobile:+966506426704

We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…